Curr Opin Chem Biol. 2020;57:8-16.

Curr Opin Chem Biol.               online article

Proteolysis targeting chimeras (PROTACs) are heterobifunctional molecules and allow selective protein degradation by addressing the natural ubiquitin proteasome system. In this review, we will discuss and summarize recent advances in PROTAC discovery with focus on epigenetic targets.