CIBSS - Centre for integrative Biological Signalling Studies CIBSS

Human atrial fibroblast adaptation to heterogeneities in substrate stiffness

Emig R, Zgierski-Johnston CM, Beyersdorf F, Rylski B, Ravens U, Weber W, Kohl P, Hörner M, Peyronnet R.

Front Physiol. 2020;10:1526.

Front Physiol.                online article

Fibrosis is accompanied by significant changes in tissue mechanics. Using light-tunable hydrogels, we show that the pro-fibrotic response of human atrial fibroblasts in response to substrate stiffness can be tuned by cell contact-mediated and paracrine communication between fibroblast populations.