Maintaining proteostasis under mechanical stress.

Höhfeld J, Benzing T, Bloch W, Fürst DO, Gehlert S, Hesse M, Hoffmann B, Hoppe T, Huesgen PF, Köhn M, Kolanus W, Merkel R, Niessen CM, Pokrzywa W, Rinschen MM, Wachten D, Warscheid B.

EMBO Rep. 2021; doi: 10.15252/embr.202152507.

For a long time mechanical stress was not recognized as a primary stressor that perturbs protein structure and threatens proteome integrity. Here, we provide an overview of recent advances in our understanding of mechanical stress protection.