CIBSS - Centre for integrative Biological Signalling Studies CIBSS

Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease

Schäffner E, Bosch-Queralt M, Edgar JM, Lehning M, Strauß J, Fleischer N, Kungl T, Wieghofer P, Berghoff SA, Reinert T, Krueger M, Morawski M, Möbius W, Barrantes-Freer A, Stieler J, Sun T, Saher G, Schwab MH, Wrede C, Frosch M, Prinz M, Reich DS, Flügel A, Stadelmann C, Fledrich R, Nave KA, Stassart RM.

Nat Neurosci. 2023; doi: 10.1038/s41593-023-01366-9

We demonstrate that myelin ensheathment itself becomes detrimental for axonal survival and increases the risk of axons degenerating in an autoimmune environment.