Oncometabolite 5-IP7 inhibits inositol 5-phosphatase to license E-cadherin endocytosis
Zhang H, Zhang B, Zhao Y, Su Y, Peng Y, Yang X, Zhao H, Liu H, Feng J, Pei H, Zhang W, Huang N, Jiang K, Ito M, Liu G, Jork N, Anderson KE, Zhao L, Nagata E, Jessen HJ, Hawkins PT, Du C, Rao F.
Dextran sulfate sodium (DSS) is a colitis inducer with a poorly understood mechanism. We demonstrate that DSS stimulates the ROS-Src-IP6K2 signaling axis producing 5-IP7, inhibiting PI(4,5)P2 phosphatases
