CIBSS - Centre for integrative Biological Signalling Studies CIBSS

Production of human papillomavirus type 16 virus-like particles in Physcomitrella photobioreactors

Niederau PA, Weilguny MC, Chamas S, Turney CE, Parsons J, Rodríguez-Franco M, Hoernstein SNW, Decker EL, Simonsen HT, Reski R.

Plant Cell Rep. 2025; doi: 10.1007/s00299-025-03602-x

In this study Physcomitrella was engineered to produce HPV-16 L1 protein. L1 was purified from 5-L photobioreactors and successfully assembled into virus-like particles (VLPs), representing the first VLP production in a non-vascular plant. HPV VLPs are the basis of licensed HPV vaccin