CIBSS - Centre for integrative Biological Signalling StudiesCIBSS

Pyridinium Modified Anthracenes and Their Endoperoxides Provide a Tunable Scaffold with Activity against Gram-Positive and Gram-Negative Bacteria

Wang X, Bittner T, Milanov M, Kaul L, Mundinger S, Koch HG, Jessen-Trefzer C, Jessen HJ.

ACS Infect Dis. 2021; doi: 10.1021/acsinfecdis.1c00263

The combination of a singlet oxygen releasing warhead with a membrane targeting bis-quaternary pyridinium headgroup embedded in an anthracene leads to novel antibiotics with broad spectrum activity.