14 Jul 2025

Response of spatially defined microglia states with distinct chromatin accessibility in a mouse model of Alzheimer's disease

Alberto Ardura-Fabregat, Lance Fredrick Pahutan Bosch, Emile Wogram, Omar Mossad, Roman Sankowski, Philipp Aktories, Lina Kieger, James Cook, Dilara Hasavci, Hatice Ulupinar, Daniel Brock, Fang Wang, Nicola Iovino, Samuel Wald, Sebastian Preissl, Bahtiyar Yilmaz, Daniel Schnepf, Andrew J. Macpherson, Thomas Blank, Katrin Kierdorf & Marco Prinz

Nature Neuroscience, https://doi.org/10.1038/s41593-025-02006-0

Microglial spatial heterogeneity remains a crucial yet not fully answered
question in the context of potential cell-directed therapies in neuodegenerative diseases. Here, we show that microglia states and their dynamics can have distinct contributions to AD and maybe targeted for treatment.