CIBSS - Centre for integrative Biological Signalling Studies CIBSS

Stress-induced nuclear condensation of NELF drives transcriptional downregulation

Rawat P, Boehning M, Hummel B, Aprile-Garcia F, Pandit AS, Eisenhardt N, Khavaran A, Niskanen E, Vos SM, Palvimo JJ, Pichler A, Cramer P, Sawarkar R.

Mol Cell. 2021; doi: 10.1016/j.molcel.2021.01.016

Rawat et al. discovered stress-induced condensation of the transcriptional regulator NELF in human cells, recapitulated by phase separation of recombinant NELF in vitro. NELF condensation is governed by its disordered tentacles and stresscontingent changes in NELF phosphorylation and SUMOylation.