CIBSS - Centre for integrative Biological Signalling Studies CIBSS

Stretch-Induced Increase in Ca2+-Spark Rate in Rabbit Atrial Cardiomyocytes Requires TRPA1 and Intact Microtubule Network

Fu J, Cameron BA, Schönleitner P, Schiatti T, Kuiper M, Kittel AS, Simon-Chica A, Madl J, Kreutz C, Filgueiras-Rama D, Schotten U, Römer W, Ravens U, Kohl P, Rog-Zielinska EA, Antoons G, Peyronnet R.

J Am Heart Assoc. 2025; doi: 10.1161/JAHA.124.040495

Mechanical stretch of the myocardium is proarrhythmic and alters cellular Ca2+ handling.This study found that in atrial cardiomyocytes,stretch increases Ca2+ spark rate via TRPA1 channels and intact microtubules, independently of redox signalling,highlighting TRPA1’s role in arrhythmia development.