CIBSS - Centre for integrative Biological Signalling Studies CIBSS

The membrane transporter SLC25A48 enables transport of choline into human mitochondria

Patil S, Borisov O, Scherer N, Wirth C, Schlosser P, Wuttke M, Ehret S, Hannibal L, Eckardt K-U, Hunte C, Neubauer B, Köttgen A, Köttgen M.

Kidney Int. 2025; doi: 10.1016/j.kint.2024.06.022.

Choline is a precursor of signaling molecules including phospholipids and acetylcholine. Its transport across membranes is poorly understood. Here we show that SLC25A48 is a human mitochondrial choline transporter. SLC25A48 mutations in humans are associated with elevated choline in body fluids.