Associate Investigators · Investigators
Dr. Valerie Hilgers
Contact
Dr. Valerie Hilgers
(she/her)
Max Planck Institute of Immunobiology and Epigenetics Freiburg
Max Planck Institute of Immunobiology and Epigenetics Freiburg
T +49 761 5108 280
hilgers(at)ie-freiburg.mpg.de
Further Information
10 selected publications:
- Sites of transcription initiation drive mRNA isoform selection.
Alfonso-Gonzalez C, Legnini I, Holec S, Arrigoni L, Bönisch U, Rybak-Wolf Agniezka, Rajewsky N, Hilgers V* (2023).
Cell 186, in press. Early online release: doi.org/10.1016/j.cell.2023.04.012. - The long non-coding RNA mimi scaffolds neuronal granules to maintain nervous system maturity.
Grzejda D, Mach J, Schweizer JA, Hummel B, Rezansoff AM, Eggenhofer F, Panhale A, Lalioti ME, Cabezas-Wallscheid N, Backofen R, Felsenberg J, Hilgers V* (2022).
Science Advances 8: eabo5578. - A critical developmental window for ELAV/Hu-dependent mRNA signatures at the onset of neuronal differentiation.
Carrasco J, Mateos F, Hilgers V* (2022).
Cell Reports 41: 111542. - Regulation of neuronal RNA signatures by ELAV/Hu proteins.
Hilgers V* (2022).
Wiley Interdiscip Rev RNA e1733. - ELAV and FNE Determine Neuronal Transcript Signatures through EXon-Activated Rescue.
Carrasco J, Rauer M, Hummel B, Grzejda D, Alfonso-Gonzalez C, Lee Y, Wang Q, Puchalska M, Mittler G, Hilgers V (2020).
Mol Cell. 80(1):156-163.e6. - The PSI-U1 snRNP
interaction regulates male mating behavior in Drosophila.
Wang Q, Taliaferro JM, Klibaite U, Hilgers V, Shaevitz JW, Rio DC (2016).
Proc Natl Acad Sci U S A 113, 5269-5274. - Alternative polyadenylation coupled to transcription initiation: Insights from ELAV-mediated 3’ UTR extension.
Hilgers V (2015).
RNA Biol. 12, 918-921. Review article. - ELAV links paused Pol II to alternative polyadenylation in the Drosophila nervous system.
Oktaba K, Zhang W, Lotz TS, Jun DJ, Lemke SB, Ng SP, Esposito E, Levine M*, Hilgers V* (2015).
Mol Cell 57, 341-348. *corresponding authors - ELAV mediates 3’ UTR extension in the Drosophila nervous system.
Hilgers V, Lemke SB, Levine M (2012).
Genes Dev. 26, 2259-2264. - Neural-specific elongation of 3’ UTRs during Drosophila development.
Hilgers V, Perry MW, Hendrix D, Stark A, Levine M, Haley B (2011).
Proc Natl Acad Sci U S A 108, 15864- 15869.