Associate Investigators

Dr. Valerie Hilgers

Dr. Valerie Hilgers

Kontakt

Dr. Valerie Hilgers
(she/her)

Max Planck Institute of Immunobiology and Epigenetics Freiburg

T +49 761 5108 280
hilgers(at)ie-freiburg.mpg.de

Weitere Informationen

10 selected publications:

  • Sites of transcription initiation drive mRNA isoform selection.
    Alfonso-Gonzalez C, Legnini I, Holec S, Arrigoni L, Bönisch U, Rybak-Wolf Agniezka, Rajewsky N, Hilgers V* (2023).
    Cell 186, in press. Early online release: doi.org/10.1016/j.cell.2023.04.012.
  • The long non-coding RNA mimi scaffolds neuronal granules to maintain nervous system maturity.
    Grzejda D, Mach J, Schweizer JA, Hummel B, Rezansoff AM, Eggenhofer F, Panhale A, Lalioti ME, Cabezas-Wallscheid N, Backofen R, Felsenberg J, Hilgers V* (2022).
    Science Advances 8: eabo5578.
  • A critical developmental window for ELAV/Hu-dependent mRNA signatures at the onset of neuronal differentiation.
    Carrasco J, Mateos F, Hilgers V* (2022).
    Cell Reports 41: 111542.
  • Regulation of neuronal RNA signatures by ELAV/Hu proteins.
    Hilgers V* (2022).
    Wiley Interdiscip Rev RNA e1733.
  • ELAV and FNE Determine Neuronal Transcript Signatures through EXon-Activated Rescue.
    Carrasco J, Rauer M, Hummel B, Grzejda D, Alfonso-Gonzalez C, Lee Y, Wang Q, Puchalska M, Mittler G, Hilgers V (2020).
    Mol Cell. 80(1):156-163.e6.
  • The PSI-U1 snRNP 
interaction regulates male mating behavior in Drosophila.
    Wang Q, Taliaferro JM, Klibaite U, Hilgers V, Shaevitz JW, Rio DC (2016).
    Proc Natl Acad Sci U S A 113, 5269-5274. 

  • Alternative polyadenylation coupled to transcription initiation: Insights from ELAV-mediated 3’ UTR extension.
    Hilgers V (2015).
    RNA Biol. 12, 918-921. Review article. 

  • ELAV links paused Pol II to alternative polyadenylation in the Drosophila nervous system.
    Oktaba K, Zhang W, Lotz TS, Jun DJ, Lemke SB, Ng SP, Esposito E, Levine M*, Hilgers V* (2015).
    Mol Cell 57, 341-348. *corresponding authors
  • ELAV mediates 3’ UTR extension in the Drosophila nervous system.
    Hilgers V, Lemke SB, Levine M (2012).

    Genes Dev. 26, 2259-2264.
  • Neural-specific elongation of 3’ UTRs during Drosophila development.
    Hilgers V, Perry MW, Hendrix D, Stark A, Levine M, Haley B (2011).
    Proc Natl Acad Sci U S A 108, 15864- 15869.