CIBSS - Centre for integrative Biological Signalling Studies CIBSS

A Noelin-organized extracellular network of proteins required for constitutive and context-dependent anchoring of AMPA-receptors

Boudkkazi S, Schwenk J, Nakaya N, Brechet A, Kollewe A, Harada H, Bildl W, Kulik A, Dong L, Sultana A, Zolles G, Schulte U, Tomarev S, Fakler B.

Neuron. 2023; doi: 10.1016/j.neuron.2023.07.013.

Processing and storage of information in the brain rely on AMPA-receptors and their context-dependent dynamics. This work shows that distribution and dynamics of AMPAR-receptors in the surface membrane are controlled by Noelins, secreted proteins that are abundantly expressed throughout the brain.