Barz S, Hofmann K, Reggiori F, Kraft C.
J Mol Biol. 2024; doi: 10.1016/j.jmb.2024.168588. Online ahead of print.
ATG8 proteins are crucial for autophagy, binding to lipids via a glycine residue. A C-terminal extension shields this site, requiring ATG4 protease priming before lipidation. This study addresses the extension's elusive function in ATG8 proteins.
