CIBSS - Centre for integrative Biological Signalling Studies CIBSS

Nonpermissive bone marrow environment impairs early B-cell development in common variable immunodeficiency

Troilo A, Wehr C, Janowska I, Venhoff N, Thiel J, Rawluk J, Frede N, Staniek J, Lorenzetti R, Schleyer MT, Herget GW, Konstantinidis L, Erlacher M, Proietti M, Camacho-Ordonez N, Voll RE, Grimbacher B, Warnatz K, Salzer U, Rizzi M.

Blood. 2020;135(17):1452-1457.

Blood                online article

Our study shows that impairment of the bone marrow niche can contribute to B-cell defects associated with the pathogenesis of CVID. In patients with nonpermissive bone marrow environment, hematopoietic stem cell transplantation would result in defective B-cell repopulation.