CIBSS - Centre for integrative Biological Signalling Studies CIBSS

Immunoproteasome-specific subunit PSMB9 induction is required to regulate cellular proteostasis upon mitochondrial dysfunction

Kim M, Serwa RA, Samluk L, Suppanz I, Kodroń A, Stępkowski TM, Elancheliyan P, Tsegaye B, Oeljeklaus S, Wasilewski M, Warscheid B, Chacinska A.

Nat Commun. 2023; doi: 10.1038/s41467-023-39642-8.

We discovered a mechanism that protects human cells against proteotoxicity caused by dysfunctional mitochondria. It involves upregulation of the chaperone HSPB1 and the immunoproteasome ß-subunit PSMB9, which promotes protein degradation by enhancing proteasome activity at the site of mitochondria.