CIBSS - Centre for integrative Biological Signalling Studies CIBSS

InsP7 is a small-molecule regulator of NUDT3-mediated mRNA decapping and processing-body dynamics.

Sahu S, Wang Z, Jiao X, Gu C, Jork N, Wittwer C, Li X, Hostachy S, Fiedler D, Wang H, Jessen HJ, Kiledjian M, Shears SB.

Proc Natl Acad Sci U S A. 2020;117(32):19245-19253

Proc Natl Acad Sci U S A.               online article

 The inositol pyrophosphate InsP7 regulates mRNA decapping by inhibiting NUDT3 in vitro and in vivo. Elevated levels of InsP7 are paralleled by an increase in the number of processing bodies in cells.