Eisenbeis VB, Qiu D, Gorka O, Strotmann L, Liu G, Prucker I, Su XB, Wilson MSC, Ritter K, Loenarz C, Groß O, Saiardi A, Jessen HJ.
Proc Natl Acad Sci U S A 2023; doi: 10.1073/pnas.2306868120.
We study the effect of exogenous and endogenous ROS on inositol pyrophosphate levels under normoxia and hypoxia. We show that the phase 2 drug beta lapachone reduces inositol pyrophosphate levels in an oxygen and NQO1 dependent manner.
