Reprogramming of the transcriptome after heat stress mediates heat hormesis in Caenorhabditis elegans

Xu F, Li R, von Gromoff ED, Drepper F, Knapp B, Warscheid B, Baumeister R, Qi W.

Nat Commun. 2023; doi: 10.1038/s41467-023-39882-8.

Here we discovered that the poly-U specific endoribonuclease ENDU-2/ENDOU activates a transcriptional reprogramming after a brief heat shock and this has a long-term beneficial effect in the model organism C. elegans.