Principal Investigators

Prof. Dr. Wolfgang Schamel

Prof. Dr. Wolfgang Schamel


Prof. Dr. Wolfgang Schamel
Institute of Biology III – Immunology (Faculty of Biology)
University of Freiburg

T +49 761 203 67511

Further Information


10 selected publications

  • Synthetic TRuC receptors engaging the complete T cell receptor for potent anti-tumor response.
    Baeuerle PA, Ding J, Patel E, Thorausch N, Horton H, Gierut J, Scarfo I, Choudhary R, Kiner O, Krishnamurthy J, Le B, Morath A, Baldeviano GC, Quinn J, Tavares P, Wei Q, Weiler S, Maus MV, Getts D, Schamel WW, Hofmeister R (2019).
    Nat Commun. 10(1):2087
  • Optogenetic control shows that kinetic proofreading regulates the activity of the T cell receptor.
    Yousefi OS, Günther M, Hörner M, Chalupsky J, Wess M, Brandl SM, Smith RW, Fleck C, Kunkel T, Zurbriggen MD, Höfer T, Weber W, Schamel WW (2019).
    Elife. 8. pii: e42475
  • Light-Controlled Affinity Purification of Protein Complexes Exemplified by the Resting ZAP70 Interactome.
    Hörner M, Eble J, Yousefi OS, Schwarz J, Warscheid B, Weber W, Schamel WWA (2019).
    Front Immunol. 10:226.
  • A cholesterol-based allostery model of T cell receptor phosphorylation.
    Swamy M, Beck-Garcia K, Beck-Garcia E, Hartl FA, Morath A, Yousefi OS, Dopfer EP, Molnar E, Schulze AK, Blanco R, Borroto A, Martin-Blanco N, Alarcon B, Hofer T, Minguet S, Schamel WW (2016).
    Immunity 44, 1091-101.
  • Inhibition of T cell receptor signaling by cholesterol sulfate, a naturally occurring derivative of membrane cholesterol.
    Wang F, Beck-Garcia K, Zorzin C, Schamel WW, Davis MM (2016).
    Nat Immunol. 17, 844-50.
  • Kidins220/ARMS binds to the B cell antigen receptor and regulates B cell development and activation.
    Fiala GJ, Janowska I, Prutek F, Hobeika E, Satapathy A, Sprenger A, Plum T, Seidl M, Dengjel J, Reth M, Cesca F, Brummer T, Minguet S, Schamel WW (2015).
    J Exp Med. 212, 1693-708.
  • The CD3 conformational change in the gammadelta T cell receptor is not triggered by antigens but can be enforced to enhance tumor killing.
    Dopfer EP, Hartl FA, Oberg HH, Siegers GM, Yousefi OS, Kock S, Fiala GJ, Garcillan B, Sandstrom A, Alarcon B, Regueiro JR, Kabelitz D, Adams EJ, Minguet S, Wesch D, Fisch P, Schamel WW (2014).
    Cell Rep. 7, 1704-15.
  • Full activation of the T cell receptor requires both clustering and conformational changes at CD3.
    Minguet S, Swamy M, Alarcon B, Luescher IF, Schamel WW (2007).
    Immunity 26, 43-54.
  • Coexistence of multivalent and monovalent TCRs explains high sensitivity and wide range of response.
    Schamel WW, Arechaga I, Risueño RM, van Santen HM, Cabezas P, Risco C, Valpuesta JM, Alarcón B (2005).
    J Exp Med. 202, 493-503.
  • Recruitment of Nck by CD3 epsilon reveals a ligand-induced conformational change essential for T cell receptor signaling and synapse formation.
    Gil D, Schamel WW, Montoya M, Sánchez-Madrid F, Alarcón B (2002).
    Cell 109, 901-12.