Ten selected publications
The Caspase-Activated DNase promotes cellular senescence.
Haimovici, A., Rupp, V., Amer, T., Moeed, A., Weber, A., Häcker, G.
EMBO J. (2024) doi: 10.1038/s44318-024-00163-9.
The Caspase-Activated DNase drives inflammation and contributes to defense againstviral infection. Moeed A, Thilmany N, Beck F, Puthussery BK, Ortmann N, Haimovici A, Badr MT, Haghighi EB, Boerries M, Öllinger R, Rad R, Kirschnek S, Gentle IE, Donakonda S, Petric PP, Hummel JF, Pfaffendorf E, Zanetta P, Schell C, Schwemmle M, Weber A, Häcker G.
Cell Death Differ. (2024) doi: 10.1038/s41418-024-01320-7.
Mitochondria supply sub-lethal signals for cytokine secretion and DNA-damage in H. pylori infection
Dörflinger, B., Badr, M.T., Haimovici, A., Fischer, L., Vier, J., Metz, A., Eisele, B., Bronsert, P., Aumann, K., Höppner, J., Waguia Kontchou, C., Parui, I., Weber, A., Kirschnek, S. and
Häcker, G. Cell Death Diff. (2022) 29 (11): 2218-2232 doi: 10.1038/s41418-022-01009-9.
A non-death function of the mitochondrial apoptosis apparatus in immunity. Brokatzky, D., Dörflinger, B., Haimovici, A., Weber, A., Kirschnek, S., Vier, J., Metz, A., Henschel, J., Steinfeldt, T., Gentle, I.E. and Häcker, G.
EMBO J. (2019) pii: e2018100907. doi: 10.15252/embj.2018100907.
Dynein light chain 1 induces assembly of large Bim complexes on mitochondria that
stabilise Mcl-1 and regulate apoptosis.
Singh, P.K., Roukounakis, A., Frank, D.O., Kirschnek, S., Das, K.K., Neumann, S., Madl, J., Römer, W., Zorzin, C., Borner, C., Haimovici, A., Garcia-Saez, A., Weber, A.* and Häcker, G.*
Genes & Development (2017) 31(17):1754-1769. doi: 10.1101/gad.302497.117.
Immunization against poly-N-acetylglucosamine reduces neutrophil activation and
GVHD while sparing microbial diversity.
Hülsdünker, J., Thomas, O.S., Haring, E., Unger, S., Gonzalo Núñez, N., Tugues, S., Gao, Z., Duquesne, S., Cywes-Bentley, C., Oyardi, O., Kirschnek, S., Schmitt-Graeff, A., Pabst, O., Koenecke, C., Duyster, J., Apostolova, P., Blaser, M.J., Becher, B.*, Pier, G.B.*, Häcker, G.*, Zeiser, R*.
Proc Natl Acad Sci U S A. (2019) pii: 201908549. doi: 10.1073/pnas.1908549116.
Neutrophil granulocytes recruited upon translocation of intestinal commensal
bacteria enhance graft- versus-host disease via local tissue damage.
Schwab, L., Goroncy, L., Palaniyandi, S., Gautam, S., Triantafyllopoulou, A., Mocsai, A.,
Reichardt, W., Karlsson, F. J., Radhakrishnan, S. V., Hanke, K., Schmitt-Graeff, A.,
Freudenberg, M., von Loewenich, F. D., Wolf, P., Leonhardt, F., Baxan, N., Pfeifer, D.,
Schmah, O., Schönle, A:, Martin, S. F., Mertelsmann, R., Duyster, J., Finke, J., Prinz,
M., Henneke, P, Häcker, H., Hildebrandt, G. C.*, Häcker, G.*, Zeiser, R.*
Nat. Med. (2014) 20(6):648-54. doi: 10.1038/nm.3517.
cIAPs block Ripoptosome formation, a RIP1/caspase 8 containing intracellular cell
death complex differentially regulated by cFLIP isoforms.
Feoktistova, S., Geserick, P., Kellert, B., Panayotova Dimitrova, D., Langlais, C., Hupe,
M., Cain, K., MacFarlane, M., Häcker, G. and Leverkus, M.
Mol. Cell (2011) 43(3):449-63. doi: 10.1016/j.molcel.2011.06.011
Cytopathicity of Chlamydia infection can be largely reproduced by expressing a single
chlamydial gene, Chlamydial Protease-like Activity Factor.
Paschen, S., Christian, J. G., Vier, J., Schmidt, F., Walch, A., Ojcius, D. M. and Häcker, G.
J Cell Biol. (2008) 182(1):117-27 doi: 10.1083/jcb.200804023.
BimS Induced Apoptosis Requires Mitochondrial Localization but not Interaction with
Anti-Apoptotic Bcl-2 Proteins.
Weber, A., Paschen, S. A., Heger, K., Wilfling, F., Frankenberg, T., Bauerschmitt, H., Seiffert,
B. M., Kirschnek, S., Wagner, H. and Häcker, G.
J Cell Biol. (2007) 177(4):625-36. doi: 10.1083/jcb.200610148.
* Co-senior author