Stress-granule dependent regulation of mitochondrial activity controls non-cell-autonomous stem cell tumorigenesis

Prof. Dr. Ralf Baumeister (CIBSS-AI), Institute of Biology III - Bioinformatics and Molecular Genetics (Faculty of Biology), University of Freiburg

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In this project we want to investigate how metabolic and stress inputs, via the serum-and-glucocorticoid-inducible kinase SGK-1 couple nutrients and stress to mitochondrial damage and stress granules, dynamics of which affect stem cell maintenance, and through the germline, also the fate of the following generations. For this purpose, we plan a proteomic analysis of stress granules from C. elegans and human cancer cells for the identification of conserved molecules and their regulatory pathways, focusing on components of membrane located multiprotein complexes.