Peptidomimetics to study immune receptor signaling

Prof. Dr. Maja Köhn (CIBSS-PI), Institute Biology III - Integrated Signalling Research (Faculty of Biology), University of Freiburg

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Activation of immune receptors is a key process in the immune response. General receptor activation can lead to a variety of effects, and chemical tools to specifically regulate immune receptors are lacking, hampering the study of molecular downstream effects. In order to study molecular details of immune receptor activation, we will develop light-switchable peptidomimetics that will allow controlling immune receptor activation. These chemical tools will be applied to study downstream events of receptor activation with spatio-temporal precision.


Publications resulting from the project:

Turn and Face the Strange: A New View on Phosphatases.
Köhn M.
ACS Cent Sci. 2020; doi: 10.1021/acscentsci.9b00909.

Molecular mechanism of SHP2 activation by PD-1 stimulation.
Marasco M, Berteotti A, Weyershaeuser J, Thorausch N, Sikorska J, Krausze J, Brandt HJ, Kirkpatrick J, Rios P, Schamel WW, Köhn M, Carlomagno T.
Sci Adv. 2020; doi: 10.1126/sciadv.aay4458.