Eomes cannot replace its paralog T-bet during expansion and differentiation of CD8 effector T cells

Fixemer J, Hummel JF, Arnold F, Klose CSN, Hofherr A, Weissert K, Kögl T, Köttgen M, Arnold SJ, Aichele P, Tanriver Y.

PLoS Pathog. 2020;16(9):e1008870.

PLoS Pathog             online article

Genetic gene-swapping of Eomes into the T-bet locus reveals non-redundant functions of these closely related Tbx transcription factors acting as major regulators during CD8 effector T cell expansion and differentiation in the LCMV infection model.