CIBSS - Centre for integrative Biological Signalling Studies CIBSS

AhR activation mitigates graft-versus-host disease of the central nervous system by reducing microglial NF-κB signaling

Zähringer A, Morgado I, Erny D, Ingelfinger F, Gawron J, Chatterjee S, Wenger V, Schmidt D, Schwöbel L, Adams RC, Langenbach M, Hartmann A, Osswald N, Wolf J, Schlunck G, Briquez PS, Grueter K, Ruess DA, Frew I, Burk AC, Holzmüller V, Grimbacher B, Michonneau D, Andrieux G, Socié G, Kolter J, Boerries M, Follo M, Blaeschke F, Sevenich L, Prinz M, Zeiser R, Vinnakota JM.

Blood Adv. 2025; doi: 10.1182/bloodadvances.2024015000.

We demonstrated that antibiotic treatment and a subsequent decrease of AhR-ligands resulted in increased microglia activation during CNS-GVHD.