APOE set the microglia free

Wogram E, Prinz M
Nat Immunol. 2023 Nov;24(11):1790-1791. doi: 10.1038/s41590-023-01651-6.

Mice were crossed with the APP/PS1 mouse model of Alzheimer’s disease to investigate cell-autonomous and non-autonomous effects of microglia expressing apoE3 or apoE4 in Alzheimer’s disease pathology.