CIBSS - Centre for integrative Biological Signalling Studies CIBSS

Identification and Characterization of a Blood−Brain BarrierPenetrant Inositol Hexakisphosphate Kinase (IP6K) Inhibitor

Tyler Heitmann, Gangling Liao, Glen Ernst, Michael Poslusney, Thomas van Kralingen, Ye Li, Megan Masi, Michael DePasquale, Ingrid Buchler, Huijun Wei, Gregory V. Carr, Evgeny Shlevkov, Mengsi Lu, Henning Jessen, and James C. Barrow*

https://doi.org/10.1021/acs.jmedchem.4c00190

IP6K inhibitors have seen a recent rise in development against diverse diseases, such as chronic kidney disease and fatty liver disease. However, there appear to be applications regarding psychiatric diseases. Current IP6K inhibitors lack BBB penetration ability, which is addressed in this study.