ISG15 Drives Immune Pathology and Respiratory Failure during Systemic Lymphocytic Choriomeningitis Virus Infection
Shaabani N, Zak J, Johnson JL, Huang Z, Nguyen N, Lazar DC, Vartabedian VF, Honke N, Jardine JG, Woehl J, Prinz M, Knobeloch KP, Arimoto KI, Zhang DE, Catz SD, Teijaro JR.
Our results suggest that dysregulated ISG15 production and signaling during persistent lymphocytic choriomeningitis virus infection can produce lethal immune pathology and could serve as a therapeutic target during severe viral infections with pulmonary pathological manifestations.
