Sci Adv. 2020;6(5):eaay4458.
Molecular mechanism of SHP2 activation by PD-1 stimulation
In cancer, the programmed death-1 (PD-1) pathway suppresses T cell stimulation and mediates immune escape. The phosphatase SHP2 controls the response downstream of the receptor PD-1. Here we dissect the detailed molecular mechanism of SHP2 activation by PD-1.