CIBSS - Centre for integrative Biological Signalling Studies CIBSS

The mitochondrial carrier pathway transports non-canonical substrates with an odd number of transmembrane segments

Rampelt H, Sucec I, Bersch B, Horten P, Perschil I, Martinou JC, van der Laan M, Wiedemann N, Schanda P, Pfanner N.

BMC Biol. 2020;18(1):2.

BMC Biol.               online article

Mitochondria import numerous metabolite carriers that contain an even number of transmembrane segments by a specific pathway. This study reveals an unexpected versatility of the carrier import pathway since substrates with an odd number of transmembrane segments can use the same pathway.