CIBSS - Centre for integrative Biological Signalling Studies CIBSS

Synchronized assembly of the oxidative phosphorylation system controls mitochondrial respiration in yeast

Moretti-Horten DN, Peselj C, Taskin AA, Myketin L, Schulte U, Einsle O, Drepper F, Luzarowski M, Vögtle FN.

Dev Cell. 2024; doi: 10.1016/j.devcel.2024.02.011.

Correct protein stoichiometry is essential for cellular function and mitochondrial oxidative phosphorylation requires tight control of the electron transport chain and ATP synthase ratio. Moretti-Horten et al. identify the MiRA platform on which ETC and ATP synthase biogenesis are synchronized.