The cobalamin processing enzyme of Trichoplax adhaerens

Krams C, Esser AJ, Klenzendorf M, Klotz K, Spiekerkoetter U, Jacobsen DW, Smith CA, Maggiolo AO, Hannibal L.

J Biol Chem. 2025; doi: 10.1016/j.jbc.2024.108089.

TaCblC from Trichoplax adhaerens processes B12 like human CblC but with faster MeCbl dealkylation and higher electron leak. Structural and functional similarities suggest evolutionary conservation, while its reactivity reflects adaptation to low oxygen and scarce B12 in marine environments.