Principal Investigators

Prof. Dr. Asifa Akhtar

Prof. Dr. Asifa Akhtar

Kontakt

Prof. Dr. Asifa Akhtar
Max Planck Institute of Immunobiology and Epigenetics Freiburg

T +49 761 5108 565
akhtar(at)ie-freiburg.mpg.de

Weitere Informationen

10 selected publications:

  • RNA nucleation by MSL2 induces selective X chromosome compartmentalization.
    Valsecchi CIK, Basilicata MF, Georgiev P, Gaub A, Seyfferth J, Kulkarni T, Panhale A, Semplicio G, Manjunath V, Holz H, Dasmeh P, Akhtar A (2021).
    Nature. 589(7840):137-142.
  • Histone H4 lysine 16 acetylation controls central carbon metabolism and diet-induced obesity in mice.
    Pessoa Rodrigues C, Chatterjee A, Wiese M, Stehle T, Szymanski W, Shvedunova M, Akhtar A (2021).
    Nat Commun. 12(1):6212.
  • Intergenerationally Maintained Histone H4 Lysine 16 Acetylation Is Instructive for Future Gene Activation.
    Samata M, Alexiadis A, Richard G, Georgiev P, Nuebler J, Kulkarni T, Renschler G, Basilicata MF, Zenk FL, Shvedunova M, Semplicio G, Mirny L, Iovino N, Akhtar A (2020).
    Cell. 182(1):127-144.e23.
  • Neural metabolic imbalance induced by MOF dysfunction triggers pericyte activation and breakdown of vasculature.
    Sheikh BN, Guhathakurta S, Tsang TH, Schwabenland M, Renschler G, Herquel B, Bhardwaj V, Holz H, Stehle T, Bondareva O, Aizarani N, Mossad O, Kretz O, Reichardt W, Chatterjee A, Braun LJ, Thevenon J, Sartelet H, Blank T, Grün D, von Elverfeldt D, Huber TB, Vestweber D, Avilov S, Prinz M, Buescher JM, Akhtar A (2020).
    Nat Cell Biol. 22(7):828-841.
  • Temporal expression of MOF acetyltransferase primes transcription factor networks for erythroid fate.
    Pessoa Rodrigues C, Herman JS, Herquel B, Valsecchi CIK, Stehle T, Grün D, Akhtar A (2020).
    Sci Adv. 6(21):eaaz4815.
  • Evolutionary conserved NSL complex/BRD4 axis controls transcription activation via histone acetylation.
    Gaub A, Sheikh BN, Basilicata MF, Vincent M, Nizon M, Colson C, Bird MJ, Bradner JE, Thevenon J, Boutros M, Akhtar A (2020).
    Nat Commun. 11(1):2243.
  • The NSL complex maintains nuclear architecture stability via lamin A/C acetylation.
    Karoutas A, Szymanski W, Rausch T, Guhathakurta S, Rog-Zielinska EA, Peyronnet R, Seyfferth J, Chen HR, de Leeuw R, Herquel B, Kimura H, Mittler G, Kohl P, Medalia O, Korbel JO, Akhtar A (2019).
    Nat Cell Biol. 21(10):1248-1260.
  • De novo mutations in MSL3 cause an X-linked syndrome marked by impaired histone H4 lysine 16 acetylation.
    Basilicata MF, Bruel AL, Semplicio G, Valsecchi CIK, Aktaş T, Duffourd Y, Rumpf T, Morton J, Bache I, Szymanski WG, Gilissen C, Vanakker O, Õunap K, Mittler G, van der Burgt I, El Chehadeh S, Cho MT, Pfundt R, Tan TY, Kirchhoff M, Menten B, Vergult S, Lindstrom K, Reis A, Johnson DS, Fryer A, McKay V; DDD Study; Fisher RB, Thauvin-Robinet C, Francis D, Roscioli T, Pajusalu S, Radtke K, Ganesh J, Brunner HG, Wilson M, Faivre L, Kalscheuer VM, Thevenon J, Akhtar A (2018).
    Nat Genet. 50(10):1442-1451.
  • DHX9 suppresses RNA processing defects originating from Alu invasion of the human genome.
    Aktas T, Ilik IA, Maticzka D, Bhardwaj V, Pessoa Rodrigues C, Mittler G., Manke T, Backofen R, Akhtar A. (2017).
    Nature 544, 115-119.
  • MOF acetyl transferase regulates transcription and respiration in mitochondria.
    Chatterjee A, Seyfferth J, Lucci J, Gilsbach R, Preissl S, Böttinger L, Mårtensson CU, Panhale A, Stehle T, Kretz O, Sahyoun AH, Avilov S, Eimer S, Hein L, Pfanner N, Becker T, Akhtar A (2016).
    Cell 67, 722-738.e23.