Principal Investigators

Dr. Nina Cabezas-Wallscheid

Dr. Nina Cabezas-Wallscheid

Kontakt

Dr. Nina Cabezas-Wallscheid
Max Planck Institute of Immunobiology and Epigenetics Freiburg

T +49 761 5108 530
cabezas(at)ie-freiburg.mpg.de

Weitere Informationen

The goal of our laboratory is to gain new biological insights on how hematopoietic stem cell dormancy is regulated. Specifically, we aim to elucidate the mechanism by which vitamin A and Gpr signaling maintain the molecular and metabolic state of dormancy. Our future findings will provide unique in-depth insight into the functional signaling networks that regulates hematopoietic stem cell fate and it can be expected that we will provide pioneering therapeutic avenues for nutritional and hematological diseases. To address these biological questions, we are pursuing interdisciplinary projects which include the use of genetic mouse models, primary patient material in combination with state-of-the-art population and single-cell OMICs analysis.

 

Keywords:

Hematopoietic stem cells, leukemic stem cells, diets, cell fate, metabolism, epigenetics, signaling, single-cell, metabolomics, in vivo.



Our ultimate goal is to translate our findings into human disease such as dietary deficiencies and leukemia

10 selected publications:

  • Hyaluronic acid–GPRC5C signalling promotes dormancy in hematopoietic stem cells.
    Zhang YW, Mess J, Aizarani N, Mishra P, Johnson C, Romero-Mulero MC, Rettkowski J, Schönberger K, Obier N, Jäcklein K, Woessner NM, Lalioti ME, Velasco-Hernandez T, Sikora K, Wäsch R, Lehnertz B, Sauvageau G, Manke T, Menendez P, Walter SG, Minguet S, Laurenti E, Günther S, Grün D, Cabezas-Wallscheid N§.
    Nature Cell Biology (2022) 10.1038/s41556-022-00931-x
  • Multilayer omics analysis reveals a non-classical signaling axis to regulate stem cell identity.
    Schönberger K*, Obier N*, Romero-Mulero MC, Cauchy P, Mess J, Pavlovich P, Zhang YW, Mitterer M, Jablanovic J, Rettkowski J, Jäcklein K, Curtis JD, Büscher J, Pearce EL, Cabezas-Wallscheid N§.
    Cell Stem Cell (2022) S1934-5909(21)00414-8.
  • Targeted LC-MS/MS-based metabolomics and lipidomics on limited hematopoietic stem cell numbers
    Schönberger K, Mitterer M, Buescher JM, Cabezas-Wallscheid N§.
    STAR Protocols (2022) 10.1016/j.xpro.2022.101408.
  • Mouse multipotent progenitor 5 cells are located at the interphase between hematopoietic stem and progenitor cells.
    Sommerkamp P*, Romero-Mulero MC*, Narr A*, Ladel L*, Hustin L, Schönberger K, Renders S, Altamura S, Zeisberger P, Jäcklein K, Klimmeck D, Rodriguez-Fraticelli A, Camargo FD, Perié L, Trumpp A **§, Cabezas-Wallscheid N**§.
    Blood (2021) 137:3218-3224.
  • Niche derived netrin-1 regulates hematopoietic stem cell dormancy via its receptor neogenin-1.
    Renders S, Svendsen AF, Panten J, Rama N, Maryanovich M, Sommerkamp P, Ladel L, Redavid AR, Gibert B, Lazare S, Ducarouge B, Schönberger K, Narr A, Tourbez M, Dethmers-Ausema B, Zwart E, Hotz-Wagenblatt A, Zhang D, Korn C, Zeisberger P, Przybylla A, Sohn M, Mendez-Ferrer S, Heikenwälder M, Brune M, Klimmeck D, Bystrykh L, Frenette PS, Mehlen P, de Haan G, Cabezas-Wallscheid N**§, Trumpp A**§.
    Nat Commun. (2021) 12:608. doi: 10.1038/s41467-020-20801-0.
  • Differential alternative polyadenylation landscapes mediate hematopoietic stem cell activation and regulate glutamine metabolism.
    Sommerkamp P, Altamura S, Renders S, Narr A, Ladel L, Zeisberger P, Eiben PL, Fawaz M, Rieger MA, Cabezas-Wallscheid N**§, Trumpp A**§.
    Cell Stem Cell (2020) 26(5):722-738.e7. doi: 10.1016/j.stem.2020.03.003.
  • The long non-coding RNA Meg3 is dispensable for adult hematopoietic stem cells.
    Sommerkamp P, Renders S, Ladel L, Hotz-Wagenblatt A, Schönberger K, Zeisberger P, Przybylla A, Sohn M, Zhou Y, Klibanski A, Cabezas-Wallscheid N**§, Trumpp A**§.
    Sci Rep. (2019) 9:2110. doi: 10.1038/s41598-019-38605-8.
  • Vitamin A-retinoic acid signaling regulates hematopoietic stem cell dormancy.
    Cabezas-Wallscheid N*§, Buettner F*, Sommerkamp P, Klimmeck D, Ladel L, Thalheimer F.B, Pastor-Flores D, Roma L.P, Renders S, Zeisberger P, Przybylla A, Schönberger K, Scognamiglio R, Altamura S, Florian M.C, Fawaz M, Vonficht D, Tesio M, Collier P, Pavlinik D, Geiger H, Schroeder T, Benes V, Dick T.B, Rieger M.A, Stegle O and Trumpp A§.
    Cell (2017) 169:807-823.e19. doi: 10.1016/j.cell.2017.04.018.

*co-first author, **co-senior author, §corresponding author.