In the Di Ventura lab, we are interested in understanding the role that dynamics play in controlling biological processes, especially gene expression in mammalian cells. To empower this type of research, we develop novel optogenetic tools to control the function and localization of proteins of interest. We also study the bacterial Min system, a beautiful example of self-organized spatially dynamic protein machinery. The LOV2 domain from Avena sativa and inteins are among our favorite molecular tools.
synthetic biology; protein engineering; optogenetics; gene expression; Min system; inteins; AsLOV2 domain