Ten Most Important Publications:
Aspirin protects against genotoxicity by promoting genome repair
Jiang H, Swacha H, Aung KM, and Gekara N.O.
Cell Research 2023 Mar 1. doi: 10.1038/s41422-023-00783-6.
The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis
Erttmann S.F., Swacha P, Aung K.M., Brindefalk B, Jiang H, Härtlova A, Uhlin B.E., Wai S.N., and Gekara N.O.*
Immunity 2022 May 10;55(5):847-861.
Nuclear AIM2-Like Receptors Drive Genotoxic Tissue Injury by Inhibiting DNA Repair
Jiang H, Swacha P, Gekara N.O.
Advanced Science 2021 Nov;8(22).
Chromatin-bound cGAS is an inhibitor of DNA repair and accelerates genome destabilization and cell death
Jiang H, Xue H, Panda S, Kawale A, Hooy R.M., Liang F, Sohn J, Sung P, and Gekara N.O.
EMBO Journal 2019 Sep 23.
Hydrogen peroxide release by bacteria suppresses inflammasome-dependent innate immunity
Erttmann S.F. and Gekara N.O.
Nature Communications 2019 Aug 2;10(1):3493.
The deubiquitinase MYSM1 dampens NOD2-mediated inflammation and tissue damage by inactivating the RIP2 complex
Panda S, and Gekara N.O.
Nature Communications 2018 Nov 7;9(1):4654.
Loss of the DNA damage repair kinase ATM impairs inflammasome-dependent antibacterial innate immunity via oxidative stress
Erttmann S.F., Hartlova A, Sloniecka M, Hosseinzadeh A, Rofougaran R, Edgren T, Raffi F.A.M, Resch U, Fällman M, Ek T, and Gekara N.O.
Immunity 2016 Jul 19;45(1):106-18.
Deubiquitinase MYSM1 Regulates Innate Immunity through Inactivation of TRAF3 and TRAF6 Complexes
Panda S, Nilsson J.A., and Gekara N.O.
Immunity 2015 Oct 20;43(4):647-59.
DNA Damage Primes the Type I Interferon System via the Cytosolic DNA Sensor STING to Promote Anti-Microbial Innate Immunity
Hartlova A, Erttmann S.F., Raffi F.A.M., Schmalz A.M., Resch U, Anugula S, Lienenklaus S, Nilsson L.M., Kröger A, Nilsson J.A., Ek T, Weiss S, and Gekara N.O.
Immunity 2015 Feb 17;42(2):332-43.
Mast cells elicit proinflammatory but not type I interferon responses upon activation of TLRs by bacteria
Dietrich N, Rohde M, Geffers R, Kroeger A, Hauser H, Weiss S, and Gekara N.O.
Proceedings of the National Academy of Sciences of the United States of America (PNAS) 2010 May 11; Vol 107(19):8748-53.