Associate Investigators

Prof. Dr. Nelson Ong´Ondo Gekara

Prof. Dr. Nelson Ong´Ondo Gekara

Kontakt

Prof. Dr. Nelson Ong´Ondo Gekara
Institute of Medical Microbiology and Hygiene,
University Medical Center - Faculty of Medicine

T +49 729430478
nelson.ongondo.gekara(at)uniklinik-freiburg.de

Weitere Informationen

10 selected publications

  • Protocol for isolation of microbiota-derived membrane vesicles from mouse blood and colon.
    Erttmann SF, Gekara
    NO. STAR Protoc. 2023 Mar 17;4(1):102046.
  • Aspirin protects against genotoxicity by promoting genome repair.
    Jiang H, Swacha P, Aung KM, Gekara NO.
    Cell Res. 2023 Apr;33(4):325-327.
  • The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis.
    Erttmann SF, Swacha P, Aung KM, Brindefalk B, Jiang H, Härtlova A, Uhlin BE, Wai SN, Gekara NO.
    Immunity. 2022 May 10;55(5):847-861.e10.
  • Nuclear AIM2-Like Receptors Drive Genotoxic Tissue Injury by Inhibiting DNA Repair.
    Jiang H, Swacha P, Gekara NO.
    Adv Sci (Weinh). 2021 Nov;8(22):e2102534
  • Chromatin-bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization and cell death.
    Jiang H, Xue X, Panda S, Kawale A, Hooy RM, Liang F, Sohn J, Sung P, Gekara NO.
    EMBO J. 2019 Oct 4;38(21):e102718.
  • Hydrogen peroxide release by bacteria suppresses inflammasome-dependent innate immunity.
    Erttmann SF, Gekara NO.
    Nat Commun. 2019 Aug 2;10(1):3493.
  • The deubiquitinase MYSM1 dampens NOD2-mediated inflammation and tissue damage by inactivating the RIP2 complex.
    Panda S, Gekara NO.
    Nat Commun. 2018 Nov 7;9(1):4654.
  • Loss of the DNA Damage Repair Kinase ATM Impairs Inflammasome-Dependent Anti-Bacterial Innate Immunity.
    Erttmann SF, Härtlova A, Sloniecka M, Raffi FAM, Hosseinzadeh A, Edgren T, Rofougaran R, Resch U, Fällman M, Ek T, Gekara NO.
    Immunity. 2017 Dec 19;47(6):1210-1211.
  • Deubiquitinase MYSM1 Regulates Innate Immunity through Inactivation of TRAF3 and TRAF6 Complexes.
    Panda S, Nilsson JA, Gekara NO.
    Immunity. 2015 Oct 20;43(4):647-59.
  • DNA damage primes the type I interferon system via the cytosolic DNA sensor STING to promote anti-microbial innate immunity.
    Härtlova A, Erttmann SF, Raffi FA, Schmalz AM, Resch U, Anugula S, Lienenklaus S, Nilsson LM, Kröger A, Nilsson JA, Ek T, Weiss S, Gekara NO.
    Immunity. 2015 Feb 17;42(2):332-343.
  • Mast cells elicit proinflammatory but not type I interferon responses upon activation of TLRs by bacteria.
    Dietrich N, Rohde M, Geffers R, Kröger A, Hauser H, Weiss S, Gekara NO.
    Proc Natl Acad Sci U S A. 2010 May 11;107(19):8748-53.