Principal Investigators

Prof. Dr. Olaf Groß

Prof. Dr. Olaf Groß

Kontakt

Prof. Dr. Olaf Groß
Institute of Neuropathology
University Medical Center, Faculty of Medicine

T +49 761 270 63810
olaf.gross(at)uniklinik-freiburg.de

Weitere Informationen

10 selected publications

  • Tyrosine kinase inhibitors trigger lysosomal damage-associated cell lysis to activate the NLRP3 inflammasome.
    Neuwirt E, Magnani G, Ćiković T, Kostina A, Wöhrle S, Flemming S, Fischer L, Fischenich NJ, Saller BS, Gorka O, Renner S, Agarinis C, Parker C, Boettcher A, Farady CJ, Backofen R, Rodriguez-Franco M, Tholen M, Reinheckel T, Ott T, Groß CJ, Jost PJ, Groß O. (2023)
    Science Signaling 16 (768) DOI: 10.1126/scisignal.abh1083
  • Human TH17 cells engage gasdermin E pores to release IL-1α on NLRP3 inflammasome activation.
    Chao YY, Puhach A, Frieser D, Arunkumar M, Lehner L, Seeholzer T, Garcia-Lopez A, van der Wal M, Fibi-Smetana S, Dietschmann A, Sommermann T, Ćiković T, Taher L, Gresnigt MS, Vastert SJ, van Wijk F, Panagiotou G, Krappmann D, Groß O, Zielinski CE. (2023)
    Nat Immunol. 24(2):295-308. doi: 10.1038/s41590-022-01386-w.
  • Metabolic reprogramming of donor T cells enhances graft-versus-leukemia effects in mice and humans.
    Uhl FM, Chen S, O'Sullivan D, Edwards-Hicks J, Richter G, Haring E, Andrieux G, Halbach S, Apostolova P, Büscher J, Duquesne S, Melchinger W, Sauer B, Shoumariyeh K, Schmitt-Graeff A, Kreutz M, Lübbert M, Duyster J, Brummer T, Boerries M, Madl T, Blazar BR, Groß O, Pearce EL, and Zeiser R. (2020)
    Sci Transl Med. 12(567):eabb8969.
  • The inflammasome drives GSDMD-independent secondary pyroptosis and IL-1 release in the absence of caspase-1 protease activity.
    Schneider KS, Groß CJ, Dreier RF, Saller BS, Mishra R, Gorka O, Heilig R, Meunier E, Dick MS, Cikovic T, Sodenkamp J, Médard G, Naumann R, Ruland J, Kuster B, Broz P, Groß O. (2017).
    Cell Reports 21, 3846-3859.
  • K+ efflux-independent NLRP3 inflammasome activation by small molecules targeting mitochondria.
    Groß CJ, Mishra R, Schneider KS, Médard G, Wettmarshausen J, Dittlein DC, Shi H, Gorka O, Koenig PA, Fromm S, Magnani G, Cikovic T, Hartjes L, Smollich J, Robertson AAB, Cooper MA, Schmidt-Supprian M, Schuster M, Schroder K, Broz P, Traidl-Hoffmann C, Beutler B,10 Kuster B, Ruland J, Schneider S, Perocchi F, Groß O (2016).
    Immunity 45, 761-773.
  • Inflammasome activators induce interleukin-1α secretion via distinct pathways with differential requirement for the protease function of caspase-1.
    Groß O*, Yazdi AS*, Thomas CJ, Masin M, Heinz LX, Guarda G, Quadroni M, Drexler SK, and Tschopp J (2012).
    Immunity 36, 388-400.
  • Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production.
    Poeck H*, Bscheider M*, Groß O*, Finger K, Roth S, Rebsamen M, Hannesschlager N, Schlee M, Rothenfusser S, Barchet W, Kato H, Akira S, Inoue S, Endres S, Peschel C, Hartmann G, Hornung V, Ruland J (2010).
    Nat Immunol. 11, 63-69.
  • Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence.
    Groß O*, Poeck H*, Bscheider M, Dostert C, Hannesschlager N, Endres S, Hartmann G, Tardivel A, Schweighoffer E, Tybulewicz V, Mocsai A, Tschopp J, Ruland J (2009).
    Nature 459, 433-436.
  • Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity.
    Groß O, Gewies A, Finger K, Schafer M, Sparwasser T, Peschel C, Forster I, Ruland J (2006).
    Nature 442, 651-656.