The core scientific interest of the group is best labeled as “Development of cellular innate immunity at interfaces”. Of particular interest are cellular programs and microenvironmental signals in site specific differentiation and adaptation of tissue macrophages throughout life, i.e. starting in utero, and extending from bone-marrow to critical body sites (e.g. skin, lung, intestine). We combine experimental infection models in mice and in vitro, high resolution imaging, multi-color flow cytometry, single cell transcriptomics and metabolic analysis to break new ground in understanding and modulating limits of cellular plasticity. Our research is of particular importance for understanding postnatal development of natural immunity, and ultimately enables the design of intervention strategies combatting infectious diseases and propagating tissue repair from early on.
Macrophages, tissue immunity, development of resistance against bacterial infections, myeloid cell origin and plasticity