A strategy to disentangle direct and indirect effects on (de)phosphorylation by chemical modulators of the phosphatase PP1 in complex cellular contexts
Hoermann et al. describe a strategy to monitor the complex effects of chemical modulation of the protein phosphatase-1 on the phosphoproteome, offering high confidence PP1 substrates, and giving insights into the effect of the modulator on the complex network of protein (de)phosphorylation.