A strategy to disentangle direct and indirect effects on (de)phosphorylation by chemical modulators of the phosphatase PP1 in complex cellular contexts

Hoermann B, Dürr EM, Ludwig C, Ercan M, Köhn M

Chem Sci. 2024 Jan 12; doi: 10.1039/d3sc04746f.

Hoermann et al. describe a strategy to monitor the complex effects of chemical modulation of the protein phosphatase-1 on the phosphoproteome, offering high confidence PP1 substrates, and giving insights into the effect of the modulator on the complex network of protein (de)phosphorylation.