Ng MY, Wang H, Zhang H, Prucker I, Perera L, Goncharova E, Wamiru A, Jessen HJ, Stanley RE, Shears SB, Luo J, O'Keefe BR, Wilson BAP.
J Biol Chem. 2025; doi: 10.1016/j.jbc.2025.108274.
ITPK1 is an important kinase/phosphatase within the inositol network that regulates diverse functions, such as growth. A high-throughput screen is developed to identify new scaffolds as inhibitors of ITPK1 and the new molecules are validated.
