CIBSS - Centre for integrative Biological Signalling Studies CIBSS

Non-apoptotic FAS signaling controls mTOR activation and extrafollicular maturation in human B cells

Staniek J, Kalina T, Andrieux G, Boerries M, Janowska I, Fuentes M, Díez P, Bakardjieva M, Stancikova J, Raabe J, Neumann J, Schwenk S, Arpesella L, Stuchly J, Benes V, García Valiente R, Fernández García J, Carsetti R, Piano Mortari E, Catala A, de la Calle O, Sogkas G, Neven B, Rieux-Laucat F, Magerus A, Neth O, Olbrich P, Voll RE, Alsina L, Allende LM, Gonzalez-Granado LI, Böhler C, Thiel J, Venhoff N, Lorenzetti R, Warnatz K, Unger S, Seidl M, Mielenz D, Schneider P, Ehl S, Rensing-Ehl A, Smulski CR, Rizzi M.

Sci Immunol. 2024; doi: 10.1126/sciimmunol.adj5948.

The Rizzi group discovered a new non-apoptotic function of Fas in the control of the mTOR signaling pathway in human B cells, with consequences on B cell maturation between germinal center and extrafollicular response. Caspase-8 and PTEN are involved in this regulation circuit.