CIBSS - Centre for integrative Biological Signalling Studies CIBSS

Synthesis of a New Purine Analogue Class with Antifungal Activity and Improved Potency against Fungal IP3-4K

Desmarini D, Truong D, Sethiya P, Liu G, Bowring B, Jessen H, Dinh H, Cain AK, Thompson PE, Djordjevic JT.

ACS Infect Dis. 2025; doi: 10.1021/acsinfecdis.4c00975

In this paper, inhibitors are developed targeting IP3 kinase (Arg1) in pathogenic fungi, such as cryptococcus neoformans. The inhibitors are based on a purine scaffold with diverse modifications and inhibit fungal growth at low MIC50 values while working synergistically with amphotericin B.