CIBSS - Centre for integrative Biological Signalling Studies CIBSS

Synuclein α accumulation mediates podocyte injury in Fabry nephropathy

Braun F, Abed A, Sellung D, Rogg M, Woidy M, Eikrem O, Wanner N, Gambardella J, Laufer SD, Haas F, Wong MN, Dumoulin B, Rischke P, Mühlig AK, Sachs W, von Cossel K, Schulz K, Muschol N, Gersting SW, Muntau AC, Kretz O, Hahn O, Rinschen MM, Mauer M, Bork T, Grahammer F, Liang W, Eierhoff T, Römer W, Hansen A, Meyer-Schwesinger C, Iaccarino G, Tøndel C, Marti HP, Najafian B, Puelles VG, Schell C, Huber TB.

J Clin Invest. 2023; doi: 10.1172/JCI157782.

This work reconceptualizes Fabry-associated cell injury beyond Gb3 accumulation, and introduces alpha-synuclein modulation as a potential intervention, especially for patients with Fabry nephropathy.