Disabling leading and lagging strand histone transmission causes loss of parental histones and cell viability.
Kollenstart L*, Biran A*, Alcaraz N, Reverón-Gómez N, Solis-Mezarino V, Völker-Albert M, Jenkinson F, Flury V, Groth A. Science Advances. 2025 (in press)The fork protection complex promotes symmetric histone recycling and epigenetic memory.
Charlton S*, Flury V*, Kanoh Y, Genzor AG, Kollenstart L, Ao W, Brøgger P, Weisser MB, …, Groth A, Thon G. Cell. 2024Safeguarding the epigenome through the cell cycle: A multitasking game.
Flury V, Groth A. Current Opinion in Genetics and Development. 2024Symmetric inheritance of parental histones governs epigenome maintenance and stem cell identity.
Wenger A*, Biran A*, Alcaraz N*, Redó-Riveiro A*, Sell AC#, Krautz R#, Flury V#, …, Andersson R, Brickman JM, Groth A. Nature Genetics. 2023Recycling of modified H2A-H2B provides short-term memory of chromatin states.
Flury V, Reverón-Gómez N, Alcaraz N, Stewart-Morgan KR, Wenger A, Klose RJ, Groth A. Cell. 2023Differential phosphorylation of Clr4 accompanies a histone methylation switch essential for meiosis.
Kuzdere T, Flury V, Schalch T, Iesmantavicius V, Hess D, Bühler M. EMBO Reports. 2022Accurate recycling of parental histones reproduces the histone modification landscape during DNA replication.
Reverón-Gómez N*, González-Aguilera C*, Stewart-Morgan KR*, Petryk N, Flury V, Graziano S, Johansen JV, Jakobsen JS, Alabert C, Groth A. Molecular Cell. 2018The histone acetyltransferase Mst2 protects active chromatin from epigenetic silencing by acetylating the ubiquitin ligase Brl1.
Flury V, Georgescu PR, Iesmantavicius V, Shimada Y, Kuzdere T, Braun S, Bühler M. Molecular Cell. 2017The Paf1 complex represses small-RNA-mediated epigenetic gene silencing.
Kowalik KM*, Shimada Y*, Flury V, Stadler MB, Batki J, Bühler M. Nature. 2015Characterization of phosphorylation- and RNA-dependent UPF1 interactors by quantitative proteomics.
Flury V, Restuccia U, Bachi A, Mühlemann O. Journal of Proteome Research. 2014
Associate Investigators · Investigators
Dr. Valentin Flury
Group Leader

Contact
Dr. Valentin Flury
Max Planck Institute of Immunobiology and Epigenetics Freiburg
T +49 (0)761 5108-777
flury(at)ie-freiburg.mpg.de