10 selected publications:

• Eomes and Brachyury control pluripotency exit and germ-layer segregation by changing the chromatin state
  Tosic J, Kim G J, Pavlovic M, Schroder CM, Mersiowsky SL, Barg M, Hofherr A, Probst S, Köttgen M, Hein L, and Arnold SJ. (2020)
  Nat Cell Biol 22, 135.
• Genetic studies of urinary metabolites illuminate mechanisms of detoxification and excretion in humans
  Schlosser P, Li Y, Sekula P, …, Köttgen M, Suhre K, Eckardt KU, Kastenmuller G, and Köttgen A. (2020)
  Nat Genet 52, 167-176.
• The mitochondrial transporter SLC25A25 links ciliary TRPP2 signaling and cellular metabolism
  Hofherr A, Seger C, Fitzpatrick F, Busch T, Michel E, Luan J, Osterried L, Linden F, Kramer-Zucker A, Wakimoto B, Schutze C, Wiedemann N, Artati A, Adamski J, Walz G, Kunji ERS, Montell C, Watnick T, and Köttgen M. (2018)
  PLoS Biol 16, e2005651.
• Targeted rescue of a polycystic kidney disease mutation by lysosomal inhibition
  Hofherr A, Wagner CJ, Watnick T, and Köttgen M. (2016)
  Kidney Int 89, 949-955.
• Polycystic kidney disease: Cilia and mechanosensation revisited
  Hofherr A, and Köttgen M. (2016).
  Nat Rev Nephrol 12, 318-319
• N-glycosylation determines the abundance of the transient receptor potential channel TRPP2
  Hofherr A*, Wagner C*, Fedeles S, Somlo S, and Köttgen M (2014)
  J Biol Chem 289, 14854-14867
• Primary cilia regulate mTORC1 activity and cell size through Lkb1
  Boehlke C, Kotsis F, Patel V, Braeg S, Voelker H, Bredt S, Beyer T, Janusch H, Hamann C, Godel M, Muller K, Herbst M, Hornung M, Doerken M, Köttgen M, Nitschke R, Igarashi P, Walz G, and Kuehn EW. (2010).
  Nat Cell Biol 12, 1115-1122
• Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout
  Woodward OM*, Köttgen A*, Coresh J, Boerwinkle E, Guggino WB, and Köttgen M. (2009).
  Proc Natl Acad Sci U S A 106, 10338-10342
• TRPP2 channels regulate apoptosis through the Ca2+ concentration in the endoplasmic reticulum
  Wegierski T*, Steffl D*, Kopp C*, Tauber R, Buchholz B, Nitschke R, Kuehn EW, Walz G, and Köttgen M. (2009)
  EMBO J 28, 490-499
• TRPP2 and TRPV4 form a polymodal sensory channel complex
  Köttgen M*, Buchholz B*, Garcia-Gonzalez MA, Kotsis F, Fu X, Doerken M, Boehlke C, Steffl D, Tauber R, Wegierski T, Nitschke R, Suzuki M, Kramer-Zucker A, Germino GG, Watnick T, Prenen J, Nilius B, Kuehn EW, and Walz G. (2008)
  J Cell Biol 182, 437-447