Associate Investigators

Prof. Dr. Michael Köttgen

Prof. Dr. Michael Köttgen

Kontakt

Prof. Dr. Michael Köttgen
Department of Internal Medicine IV
University Medical Center, Faculty of Medicine

T +49 761 270 63140
michael.koettgen(at)uniklinik-freiburg.de

Weitere Informationen

10 selected publications:

  • Eomes and Brachyury control pluripotency exit and germ-layer segregation by changing the chromatin state
    Tosic J, Kim G J, Pavlovic M, Schroder CM, Mersiowsky SL, Barg M, Hofherr A, Probst S, Köttgen M, Hein L, and Arnold SJ. (2020)
    Nat Cell Biol 22, 135.
  • Genetic studies of urinary metabolites illuminate mechanisms of detoxification and excretion in humans
    Schlosser P, Li Y, Sekula P, …, Köttgen M, Suhre K, Eckardt KU, Kastenmuller G, and Köttgen A. (2020)
    Nat Genet 52, 167-176.
  • The mitochondrial transporter SLC25A25 links ciliary TRPP2 signaling and cellular metabolism
    Hofherr A, Seger C, Fitzpatrick F, Busch T, Michel E, Luan J, Osterried L, Linden F, Kramer-Zucker A, Wakimoto B, Schutze C, Wiedemann N, Artati A, Adamski J, Walz G, Kunji ERS, Montell C, Watnick T, and Köttgen M. (2018)
    PLoS Biol 16, e2005651.
  • Targeted rescue of a polycystic kidney disease mutation by lysosomal inhibition
    Hofherr A, Wagner CJ, Watnick T, and Köttgen M. (2016)
    Kidney Int 89, 949-955.
  • Polycystic kidney disease: Cilia and mechanosensation revisited
    Hofherr A, and Köttgen M. (2016).
    Nat Rev Nephrol 12, 318-319
  • N-glycosylation determines the abundance of the transient receptor potential channel TRPP2
    Hofherr A*, Wagner C*, Fedeles S, Somlo S, and Köttgen M (2014)
    J Biol Chem 289, 14854-14867
  • Primary cilia regulate mTORC1 activity and cell size through Lkb1
    Boehlke C, Kotsis F, Patel V, Braeg S, Voelker H, Bredt S, Beyer T, Janusch H, Hamann C, Godel M, Muller K, Herbst M, Hornung M, Doerken M, Köttgen M, Nitschke R, Igarashi P, Walz G, and Kuehn EW. (2010).
    Nat Cell Biol 12, 1115-1122
  • Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout
    Woodward OM*, Köttgen A*, Coresh J, Boerwinkle E, Guggino WB, and Köttgen M. (2009).
    Proc Natl Acad Sci U S A 106, 10338-10342
  • TRPP2 channels regulate apoptosis through the Ca2+ concentration in the endoplasmic reticulum
    Wegierski T*, Steffl D*, Kopp C*, Tauber R, Buchholz B, Nitschke R, Kuehn EW, Walz G, and Köttgen M. (2009)
    EMBO J 28, 490-499
  • TRPP2 and TRPV4 form a polymodal sensory channel complex
    Köttgen M*, Buchholz B*, Garcia-Gonzalez MA, Kotsis F, Fu X, Doerken M, Boehlke C, Steffl D, Tauber R, Wegierski T, Nitschke R, Suzuki M, Kramer-Zucker A, Germino GG, Watnick T, Prenen J, Nilius B, Kuehn EW, and Walz G. (2008)
    J Cell Biol 182, 437-447