Centre for Integrative Biological Signalling Studies
Cluster of Excellence, University of Freiburg

Dr. Clemens Kreutz

Dr. Clemens Kreutz

Methods of Modelling and Bioinformatics in Systems Biomedicine (MSB)
Institute of Medical Biometry and Statistics (IMBI)
(University Medical Center, Faculty of Medicine)

+49 761 203 54281

CIBSS Research Project:


10 selected publications:

  • Guidelines for benchmarking of optimization-based approaches for fitting mathematical models.
    Kreutz C (2019).
    Genome Biol. 20(1):281.
  • Benchmark problems for dynamic modeling of intracellular processes.
    Hass H, Loos C, Raimúndez-Álvarez E, Timmer J, Hasenauer J, Kreutz C (2019).
    Bioinformatics. 35(17):3073-3082.
  • Quantifying post-transcriptional regulation in the development of Drosophila melanogaster.
    Becker K, Bluhm A, Casas-Vila N, Dinges N, Dejung M, Sayols S, Kreutz C, Roignant JY, Butter F, Legewie S (2018).
    Nat Commun. 9(1):4970.
  • An easy and efficient approach for testing identifiability.
    Kreutz C. (2018).
    Bioinformatics 34(11), 1913-1921.
  • Resolving the combinatorial complexity of smad protein complex formation and its link to gene expression. .
    Lucarelli P, Schilling M, Kreutz C, Vlasov A, Boehm ME, Iwamoto N, . . . Klingmüller U (2018).
    Cell Syst. 6(1), 75-89.e11.
  • Hepatocyte ploidy is a diversity factor for liver homeostasis. .
    Kreutz C, MacNelly S, Follo M, Wäldin A, Binninger-Lacour P, Timmer J, Bartolomé-Rodríguez MM (2017).
    Front Physiol.8, 862. doi:10.3389/fphys.2017.00862
  • L1 regularization facilitates detection of cell type-specific parameters in dynamical systems..
    Steiert B, Timmer J, Kreutz C (2016).
    Bioinformatics, 32(17)
  • Profile likelihood in systems biology.
    Kreutz C, Raue A, Kaschek D, Timmer J (2013).
    FEBS J 280(11), 2564-2571.
  • Likelihood based observability analysis and confidence intervals for predictions of dynamic models.
    Kreutz C, Raue A, Timmer J (2012).
    BMC Syst Biol. 6, 120.
  • Systems biology: experimental design.
    Kreutz C, Timmer J (2009).
    FEBS J. 276(4), 923-942.