Centre for Integrative Biological Signalling Studies
Cluster of Excellence, University of Freiburg

Dr. Edward Pearce

Dr. Edward Pearce

Max-Planck-Institute of Immunobiology and Epigenetics Freiburg

+49 761 5108 476

CIBSS Research Project:


10 selected publications:

  • Mitochondrial Membrane Potential Regulates Nuclear Gene Expression in Macrophages Exposed to Prostaglandin E2.
    Sanin D, Matsushita M, Klein Geltink RI, Grzes KM, van Teijlingen Bakker N, Corrado M, Kabat AM; Buck MD, Qiu J, Lawless SJ, Cameron AM, Villa M, Francesc Baixauli F, Patterson AE, Curtis JD, O’Neill CM, O’Sullivan D, Wu D, Huang SC-C, Pearce EL, Pearce EJ.
    Immunity, In press.
  • Mitochondrial Priming by CD28.
    Klein Geltink RI, O’Sullivan D, Corrado M, Bremser A, Buck MD, Buescher JM, Firat E, Zhu X, Niedermann G, Caputa G, Kelly B, Warthorst U, Rensing-Ehl A, Kyle RL, Vandersarren L, Curtis JD, Patterson AE, Lawless S, Grzes K, Qiu J, Sanin DE, Kretz O, Huber TB, Janssens S, Lambrecht BN, Rambold AS, Pearce EJ, Pearce EL (2017)
    Cell. 171(2):385-397.
  • mTORC2-IRF4 mediated metabolic reprograming is essential for macrophage alternative activation. Immunity.
    Huang, SC-C, Smith AM, Everts B, Colonna M, Pearce EL, Schilling JD, Pearce EJ (2016).
  • Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation.
    Lampropoulou V, Sergushichev A, Bambouskova M, Nair S, Vincent EE, Loginicheva E, Cervantes-Barragan L, Ma X, Huang SC, Griss T, Weinheimer CJ, Khader S, Randolph GJ, Pearce EJ, Jones RG, Diwan A, Diamond MS, Artyomov MN (2016).
    Cell Metab. 24(1):158-66.
  • Type 1 Interferons Induce Changes in Core Metabolism that Are Critical for Immune Function.
    Wu D, Sanin DE, Everts B, Chen Q, Qiu J, Buck MD, Patterson A, Smith AM, Chang CH, Liu Z, Artyomov MN, Pearce EL, Cella M, Pearce EJ (2016).
    Immunity. 44(6):1325-36.
  • Network integration of parallel metabolomics and transcriptional data reveals metabolic modules that regulate macrophage polarization.
    Jha AK, Huang SC, Sergushichev A, Lampropoulo V, Ivanova Y, Loginicheva E, Chielewski K, Stewart KM, Ashall J, Everts B, Pearce EJ*, Driggers EM*, Artyomov M* (2015).
    Immunity. 42(3):419-30. (*co-senior authors).
  • Metabolic competition in the tumor microenvironment is a driver of cancer progression.
    Chang CH, Qiu J, O'Sullivan D, Buck MD, Noguchi T, Curtis JD, Chen Q, Gindin M, Gubin MM, van der Windt GJ, Tonc E, Schreiber RD, Pearce EJ, Pearce EL (2015).
    Cell. 162(6):1229-41.
  • TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation.
    Everts B, Amiel E, Huang SC, Smith AM, Chang CH, Lam WY, Redmann V, Freitas TC, Blagih J, van der Windt GJ, Artyomov MN, Jones RG, Pearce EL, Pearce EJ (2014).
    Nat Immunol. 15:323-32.
  • Posttranscriptional control of T cell effector function by aerobic glycolysis
    Chang CH, Curtis JD, Maggi LB Jr, Faubert B, Villarino AV, O'Sullivan D, Huang SC, van der Windt GJ, Blagih J, Qiu J, Weber JD, Pearce EJ, Jones RG, Pearce EL (2013).
    Cell. 153:1239-51.
  • Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells.
    Everts B, Amiel E, van der Windt GJ, Freitas TC, Chott R, Yarasheski KE, Pearce EL, Pearce EJ (2012).
    Blood 120:1422-31.