Centre for Integrative Biological Signalling Studies
Cluster of Excellence, University of Freiburg

Jun. Prof. Dr. Katrin Kierdorf

Jun. Prof. Dr. Katrin Kierdorf

Institute of Neuropathology (University Medical Center Freiburg, Faculty of Medicine)

+49 761 270 50780

CIBSS Research Project:

 

10 selected publications:

  • Regulation of phagocyte triglyceride by a STAT-ATG2 pathway controls mycobacterial infection.
    Péan CB, Schiebler M, Tan SW, Sharrock JA, Kierdorf K, Brown KP, Maserumule MC, Menezes S, Pilátová M, Bronda K, Guermonprez P, Stramer BM, Andres Floto R, Dionne MS (2017).
    Nat Commun. 8:14642
  • Origin, fate and dynamics of macrophages at central nervous system interfaces.
    Goldmann T, Wieghofer P, Jordão MJ, Prutek F, Hagemeyer N, Frenzel K, Amann L, Staszewski O, Kierdorf K, Krueger M, Locatelli G, Hochgerner H, Zeiser R, Epelman S, Geissmann F, Priller J, Rossi FM, Bechmann I, Kerschensteiner M, Linnarsson S, Jung S, Prinz M (2016).
    Nat Immunol. 17(7):797-805.
  • Transcriptome-based profiling of yolk sac-derived macrophages reveals a role for Irf8 in macrophage maturation.
    Hagemeyer N, Kierdorf K, Frenzel K, Xue J, Ringelhan M, Abdullah Z, Godin I, Wieghofer P, Costa Jordão MJ, Ulas T, Yorgancioglu G, Rosenbauer F, Knolle PA, Heikenwalder M, Schultze JL, Prinz M (2015).
    EMBO J. 35(16):1730-44.
  • USP18 lack in microglia causes destructive interferonopathy of the mouse brain.
    Goldmann T, Zeller N, Raasch J, Kierdorf K, Frenzel K, Ketscher L, Basters A, Staszewski O, Brendecke SM, Spiess A, Tay TL, Kreutz C, Timmer J, Mancini GM, Blank T, Fritz G, Biber K, Lang R, Malo D, Merkler D, Heikenwälder M, Knobeloch KP, Prinz M (2015).
    EMBO J. 34(12):1612-29.
  • Macrophage-derived upd3 cytokine causes impaired glucose homeostasis and reduced lifespan in Drosophila fed a lipid-rich diet.
    Woodcock KJ, Kierdorf K, Pouchelon CA, Vivancos V, Dionne MS, Geissmann F (2015). Immunity. 42(1):133-44.
  • A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation.
    Goldmann T, Wieghofer P, Müller PF, Wolf Y, Varol D, Yona S, Brendecke SM, Kierdorf K, Staszewski O, Datta M, Luedde T, Heikenwalder M, Jung S, Prinz M (2013).
    Nat Neurosci. 16(11):1618-26.
  • Bone marrow cell recruitment to the brain in the absence of irradiation or parabiosis bias.
    Kierdorf K, Katzmarski N, Haas CA, Prinz M (2013).
    PLoS One. 8(3):e58544.
  • Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways.
    Kierdorf K, Erny D, Goldmann T, Sander V, Schulz C, Perdiguero EG, Wieghofer P, Heinrich A, Riemke P, Hölscher C, Müller DN, Luckow B, Brocker T, Debowski K, Fritz G, Opdenakker G, Diefenbach A, Biber K, Heikenwalder M, Geissmann F, Rosenbauer F, Prinz M (2013). Nat Neurosci. 2013 Mar;16(3):273-80.
  • A lineage of myeloid cells independent of Myb and hematopoietic stem cells .
    Schulz C, Gomez Perdiguero E, Chorro L, Szabo-Rogers H, Cagnard N, Kierdorf K, Prinz M, Wu B, Jacobsen SE, Pollard JW, Frampton J, Liu KJ, Geissmann F (2012).
    Science. 336(6077):86-90
  • Distinct and non-redundant roles of microglia and myeloid subsets in mouse models of Alzheimer's disease.
    Mildner A*, Schlevogt B*, Kierdorf K*, Böttcher C, Erny D, Kummer MP, Quinn M, Brück W, Bechmann I, Heneka MT, Priller J, Prinz M (2011).
    J Neurosci. 2011 Aug 3;31(31):11159-71. *equally contributed