Centre for Integrative Biological Signalling Studies
Cluster of Excellence, University of Freiburg

Prof. Dr. Bodo Grimbacher

Prof. Dr. Bodo Grimbacher

CCI Center for Chronic Immunodeficiency (University Medical Center Freiburg, Faculty of Medicine)

+49 761 270 77731

CIBSS Research Project:

 

10 selected publications:

  • Treatment of Progressive Multifocal Leukoencephalopathy with Pembrolizumab.
    Rauer S, Marks R, Urbach H, Warnatz K, Nath A, Holland S, Weiller C, Grimbacher B (2019).
    N Engl J Med. (letter)380(17):1676-1677.
  • ZNF341 controls STAT3 expression and thereby immunocompetence.
    Frey-Jakobs S, Hartberger JM, Fliegauf M, Bossen C, Wehmeyer ML, Neubauer JC, Bulashevska A, Proietti M, Fröbel P, Nöltner C, Yang L, Rojas-Restrepo J, Langer N, Winzer S, Engelhardt KR, Glocker C, Pfeifer D, Klein A, Schäffer AA, Lagovsky I, Lachover-Roth I, Béziat V, Puel A, Casanova JL, Fleckenstein B, Weidinger S, Kilic SS, Garty BZ, Etzioni A, Grimbacher B (2018).
    Sci Immunol. 15;3(24).
  • Haploinsufficiency of the NF-κB1 Subunit p50 in Common Variable Immunodeficiency.
    Fliegauf M, Bryant VL, Frede N, Slade C, Woon ST, Lehnert K, Winzer S, Bulashevska A, Scerri T, Leung E, Jordan A, Keller B, de Vries E, Cao H, Yang F, Schäffer AA, Warnatz K, Browett P, Douglass J, Ameratunga RV, van der Meer JW, Grimbacher B (2015).
    Am J Hum Genet. 97(3):389-403.
  • Autosomal dominant immune dysregulation syndrome in humans with CTLA4 mutations.
    Schubert D, Bode C, Kenefeck R, Hou TZ, Wing JB, Kennedy A, Bulashevska A, Petersen BS, Schäffer AA, Grüning BA, Unger S, Frede N, Baumann U, Witte T, Schmidt RE, Dueckers G, Niehues T, Seneviratne S, Kanariou M, Speckmann C, Ehl S, Rensing-Ehl A, Warnatz K, Rakhmanov M, Thimme R, Hasselblatt P, Emmerich F, Cathomen T, Backofen R, Fisch P, Seidl M, May A, Schmitt-Graeff A, Ikemizu S, Salzer U, Franke A, Sakaguchi S, Walker LSK, Sansom DM, Grimbacher B (2014).
    Nat Med. 20(12):1410-1416.
  • Inflammatory bowel disease and mutations affecting the interleukin-10 receptor.
    Glocker EO, Kotlarz D, Boztug K, Gertz EM, Schäffer AA, Noyan F, Perro M, Diestelhorst J, Allroth A, Murugan D, Hätscher N, Pfeifer D, Sykora KW, Sauer M, Kreipe H, Lacher M, Nustede R, Woellner C, Baumann U, Salzer U, Koletzko S, Shah N, Segal AW, Sauerbrey A, Buderus S, Snapper SB, Grimbacher B, Klein C (2009).
    N Engl J Med. 361(21):2033-45.
  • A homozygous CARD9 mutation in a family with susceptibility to fungal infections.
    Glocker EO, Hennigs A, Nabavi M, Schäffer AA, Woellner C, Salzer U, Pfeifer D, Veelken H, Warnatz K, Tahami F, Jamal S, Manguiat A, Rezaei N, Amirzargar AA, Plebani A, Hannesschläger N, Gross O, Ruland J, Grimbacher B (2009).
    N Engl J Med. 361(18):1727-35.
  • STAT3 mutations in the hyper-IgE syndrome.
    Holland SM, DeLeo FR, Elloumi HZ, Hsu AP, Uzel G, Brodsky N, Freeman AF, Demidowich A, Davis J, Turner ML, Anderson VL, Darnell DN, Welch PA, Kuhns DB, Frucht DM, Malech HL, Gallin JI, Kobayashi SD, Whitney AR, Voyich JM, Musser JM, Woellner C, Schäffer AA, Puck JM, Grimbacher B (2007).
    N Engl J Med. 357(16):1608-19.
  • Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans.
    Salzer U, Chapel HM, Webster AD, Pan-Hammarstrom Q, Schmitt-Graeff A, Schlesier M, Peter HH, Rochstroh JK, Schneider P, Schaffer AA, Hammarstrom L, Grimbacher B (2005).
    Nat Genet 37: 820-828.
  • Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency.
    Grimbacher B, Hutloff A, Schlesier M, Glocker E, Warnatz K, Dräger R, Eibel H, Fischer B, Schäffer AA, Mages HW, Kroczek RA, Peter HH (2003).
    Nat Immunol. 4(3):261-8.
  • Hyper-IgE syndrome with recurrent infections--an autosomal dominant multisystem disorder.
    Grimbacher B, Holland SM, Gallin JI, Greenberg F, Hill SC, Malech HL, Miller JA, O'Connell AC, Puck JM (1999).
    N Engl J Med. 340(9):692-702.